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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS3
All Species:
7.27
Human Site:
S152
Identified Species:
14.55
UniProt:
O14543
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14543
NP_003946.3
225
24770
S152
S
E
V
P
E
Q
P
S
A
Q
P
L
P
G
S
Chimpanzee
Pan troglodytes
XP_509267
198
22155
I126
F
D
S
V
V
H
L
I
D
Y
Y
V
Q
M
C
Rhesus Macaque
Macaca mulatta
XP_001106015
576
62574
S503
S
E
V
P
E
Q
P
S
A
Q
P
L
P
G
S
Dog
Lupus familis
XP_848851
225
24779
P152
S
E
V
S
E
Q
P
P
S
Q
P
L
P
G
N
Cat
Felis silvestris
Mouse
Mus musculus
O35718
225
24758
P152
S
E
V
P
E
Q
P
P
A
Q
A
L
P
G
S
Rat
Rattus norvegicus
O88583
225
24790
P152
F
E
V
Q
E
Q
P
P
A
Q
A
L
P
G
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516256
214
23730
S142
S
S
T
S
S
S
S
S
S
P
P
K
T
P
P
Chicken
Gallus gallus
Q90X67
209
23158
K137
P
T
P
C
A
G
P
K
Q
P
G
G
A
L
H
Frog
Xenopus laevis
P13116
532
59718
I425
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
Zebra Danio
Brachydanio rerio
NP_998469
210
23421
T138
H
Y
M
P
S
A
G
T
V
S
S
S
N
A
G
Tiger Blowfish
Takifugu rubipres
NP_001072096
201
22742
H129
D
C
V
L
K
L
V
H
Y
Y
M
S
Q
S
K
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799032
227
25956
S153
V
D
A
N
G
N
G
S
T
I
K
P
K
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
38.5
97.7
N.A.
96.8
95.5
N.A.
79.5
84
20.1
61.3
57.3
N.A.
N.A.
N.A.
35.2
Protein Similarity:
100
45.3
38.8
99.1
N.A.
97.3
96.4
N.A.
86.2
88.4
28.2
74.6
70.6
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
0
100
73.3
N.A.
86.6
66.6
N.A.
20
6.6
13.3
6.6
6.6
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
13.3
100
86.6
N.A.
86.6
66.6
N.A.
26.6
6.6
33.3
20
13.3
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
9
9
0
0
34
0
17
9
9
9
9
% A
% Cys:
0
9
0
9
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
9
17
0
0
0
0
0
0
9
0
0
0
0
0
0
% D
% Glu:
0
42
0
0
42
0
0
0
0
0
0
0
0
9
0
% E
% Phe:
17
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
9
9
17
0
0
0
9
9
0
42
17
% G
% His:
9
0
0
0
0
9
0
9
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
17
0
9
0
0
0
0
0
% I
% Lys:
0
0
0
0
17
0
0
9
9
0
9
9
9
0
9
% K
% Leu:
0
0
0
9
0
9
9
0
0
0
0
42
0
9
0
% L
% Met:
0
0
9
0
0
0
0
0
0
0
9
0
0
9
0
% M
% Asn:
0
0
0
9
0
9
0
0
0
0
0
0
9
0
9
% N
% Pro:
9
0
9
34
0
0
59
25
0
17
34
9
50
9
9
% P
% Gln:
0
9
0
9
0
42
0
0
9
42
0
0
17
0
0
% Q
% Arg:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% R
% Ser:
42
9
9
17
17
9
9
34
17
9
9
17
0
9
25
% S
% Thr:
0
9
9
0
0
0
0
9
9
0
9
0
9
9
0
% T
% Val:
9
0
50
9
9
0
9
0
9
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
0
9
17
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _